We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Enantioselective Construction of Axially Chiral Amino Sulfide Vinyl Arenes by Chiral Sulfide‐Catalyzed Electrophilic Carbothiolation of Alkynes.
- Authors
Liang, Yaoyu; Ji, Jieying; Zhang, Xiaoyan; Jiang, Quanbin; Luo, Jie; Zhao, Xiaodan
- Abstract
The enantioselective construction of axially chiral compounds by electrophilic carbothiolation of alkynes is disclosed for the first time. This enantioselective transformation is enabled by the use of a Ts‐protected bifunctional sulfide catalyst and Ms‐protected ortho‐alkynylaryl amines (Ts=tosyl; Ms=mesyl). Both electrophilic arylthiolating and electrophilic trifluoromethylthiolating reagents are suitable for this reaction. The obtained products of axially chiral vinyl–aryl amino sulfides can be easily converted into biaryl amino sulfides, biaryl amino sulfoxides, biaryl amines, vinyl–aryl amines, and other valuable difunctionalized compounds.
- Subjects
DIVINYL sulfide; ELECTROPHILES; ALKYNES; AROMATIC compounds; CONSTRUCTION
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 12, p4989
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201915470