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- Title
Visible‐Light Photoredox‐Catalyzed and Copper‐Promoted Trifluoromethoxylation of Arenediazonium Tetrafluoroborates.
- Authors
Yang, Shaoqiang; Chen, Miao; Tang, Pingping
- Abstract
We report the development of photoredox‐catalyzed and copper‐promoted trifluoromethoxylation of arenediazonium tetrafluoroborates, with trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxylation reagent. This new method takes advantage of visible‐light photoredox catalysis to generate the aryl radical under mild conditions, combined with copper‐promoted selective trifluoromethoxylation. The reaction is scalable, tolerates a wide range of functional groups, and proceeds regioselectively under mild reaction conditions. Furthermore, mechanistic studies suggested that a Cs[Cu(OCF3)2] intermediate might be generated during the reaction.
- Subjects
ARYL radicals; COPPER; TRIFLUOROMETHYL compounds; FUNCTIONAL groups; REGIOSELECTIVITY (Chemistry)
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 23, p7922
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201901447