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- Title
Cu<sup>I</sup>‐Mediated Bromoalkynylation and Hydroalkynylation Reactions of Unsymmetrical Benzynes: Complementary Modes of Addition.
- Authors
Xiao, Xiao; Wang, Tao; Xu, Feng; Hoye, Thomas R.
- Abstract
Benzynes formed by heating a suitable triyne (or tetrayne) substrate are shown to react with in situ generated alkynyl copper species. The latter are compatible with the polyyne substrates and two types of chemistries have been achieved: (i) 1‐bromo‐1‐alkynes efficiently undergo net bromoalkynylation of the (unsymmetrical) benzynes and (ii) in situ generated alkynylcopper species give rise to hydroalkynylation products. The regiochemical preferences of these two modes of reaction are complementary to one another with respect to the position of alkynyl substituent in the final products.
- Subjects
BENZYNES; ALKYLATION; COPPER compounds; CHEMICAL reactions; ADDITION reactions
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 50, p16802
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201811783