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- Title
Near‐Infrared Semiconducting Polymer Brush and pH/GSH‐Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor‐Specific Phototheranostics.
- Authors
Rong, Pengfei; Wang, Wei; Yang, Zhen; Fan, Wenpei; Tang, Wei; Shen, Zheyu; Dai, Yunlu; Song, Jibin; Wang, Zhantong; Liu, Yuan; Lin, Lisen; Shan, Lingling; Liu, Yijing; Jacobson, Orit; Chen, Xiaoyuan
- Abstract
Tumor‐specific phototheranostics is conducive to realizing precise cancer therapy. Herein, a novel tumor microenvironment (TME)‐responsive phototheranostic paradigm based on the combination of semiconducting polymer brushes and polyoxometalate clusters (SPB@POM) is rationally designed. The acidic TME could drive the self‐assembly of SPB@POM into bigger aggregates for enhanced tumor retention and accumulation, while the reducing TME could significantly enhance the NIR absorption of SPB@POM for significant improvement of photoacoustic imaging contrast and photothermal therapy efficacy. Therefore, the smart pH/glutathione (GSH)‐responsive SPB@POM allows for remarkable phototheranostic enhancement under the unique TME, which has potential for precise tumor‐specific phototheranostics with minimal side effects.
- Subjects
NEAR infrared spectroscopy; POLYOXOMETALATES; POLYMERS; CANCER treatment; GLUTATHIONE
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 43, p14297
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201808074