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- Title
Conformation‐Enabled Total Syntheses of Ohmyungsamycins A and B and Structural Revision of Ohmyungsamycin B.
- Authors
Hur, Joonseong; Jang, Jaebong; Sim, Jaehoon; Son, Woo Sung; Ahn, Hee‐Chul; Kim, Tae Sung; Shin, Yern‐Hyerk; Lim, Changjin; Lee, Seungbeom; An, Hongchan; Kim, Seok‐Ho; Oh, Dong‐Chan; Jo, Eun‐Kyeong; Jang, Jichan; Lee, Jeeyeon; Suh, Young‐Ger
- Abstract
Abstract: The first total syntheses of the bioactive cyclodepsipeptides ohmyungsamycin A and B are described. Key features of our synthesis include the concise preparation of a linear cyclization precursor that consists of <italic>N</italic>‐methyl amides and non‐proteinogenic amino acids, and its macrolactamization from a bent conformation. The proposed structure of ohmyungsamycin B was revised based on its synthesis. The cyclic core of the ohmyungsamycins was shown to be responsible for the excellent antituberculosis activity, and ohmyungsamycin variants with truncated chains were evaluated for their biological activity.
- Subjects
AMINO acid amides; REVISIONS
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 12, p3123
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201711286