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- Title
Insertion of Nitriles into Zirconocene 1-aza-1,3-diene Complexes: Chemoselective Synthesis of N-H and N-Substituted Pyrroles.
- Authors
Yu, Shasha; Xiong, Meijun; Xie, Xin; Liu, Yuanhong
- Abstract
The direct insertion of nitriles into zirconocene-1- aza-1,3-diene complexes provides an efficient, chemoselective, and controllable synthesis of N-H and N-substituted pyrroles upon acidic aqueous work-up. The outcome of the reaction (that is, the formation of N-H or N-substituted pyrroles) results from the different cyclization patterns, which depend on the relative stability and reactivity of the enamine-imine tautomers formed by hydrolysis of the diazazirconacycles.
- Subjects
NITRILES; ZIRCONOCENES; DIOLEFINS; PYRROLES; CHEMOSELECTIVITY; AQUEOUS solutions; HYDROLYSIS
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 43, p11780
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201407221