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- Title
Production of the antibiotic gallidermin by Staphylococcus gallinarum – development of a scale-up procedure.
- Authors
Kempf, M.; Theobald, U.; Fiedler, H.-P.
- Abstract
A scale-up strategy into 200 l pilot-scale for the production of the antibiotic gallidermin by Staphylococcus gallinarum Tü 3928 was developed. Large-scale fermentations were simulated by consecutive liquid cultures of smaller scale. Afterwards, optimised cultivation conditions were transferred to pilot-scale. Best results were achieved by addition of Maltose during the late production phase leading to a final concentration of 330 mg gallidermin per litre. Compared to the concentrations found in a non-pulsed pilot-scale fermentations this is an increase of 20–30%.
- Subjects
FERMENTATION; BIOCHEMICAL engineering; ANTIBIOTICS; FLUIDS; STAPHYLOCOCCUS; LEAVENING agents
- Publication
Biotechnology Letters, 2000, Vol 22, Issue 2, p123
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1005667406165