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- Title
Strain elastography as an early predictor of long-term prognosis in patients with locally advanced cervical cancers treated with concurrent chemoradiotherapy.
- Authors
Xu, Yan; Zhu, Lijing; Zhu, Li; Wang, Huanhuan; Ru, Tong; Liu, Baorui; He, Jian; Tian, Sibo; Zhou, Zhengyang; Yang, Xiaofeng
- Abstract
<bold>Objective: </bold>To explore the value of strain elastography as an early predictor of long-term prognosis in patients with locally advanced cervical cancers treated with concurrent chemoradiotherapy (CCRT).<bold>Methods: </bold>Strain elastography examinations were performed on 45 patients with locally advanced cervical cancers at 3 time points: prior to CCRT, and at 1 and 2 weeks after the start of CCRT. The maximum tumor diameter (Dmax), strain ratio (SR), and their percentage changes (ΔDmax and ΔSR) were calculated to predict long-term prognosis. Based on the results of physical examinations, Papanicolaou test, and pelvic magnetic resonance imaging, we classified patients into two groups: responders (complete remission) and non-responders (sustained disease, recurrence, or death).<bold>Results: </bold>After a median follow-up of 30 months (range, 12-36 months), 36 of 45 (80%) patients were disease free. The Dmax as well as ΔDmax at 2 weeks during CCRT was able to predict the responder outcomes, with an area-under-the-curve (AUC) of 0.733 and 0.731, respectively. Furthermore, significant differences in SR and ΔSR at 1 and 2 weeks during therapy were shown between the responder and non-responder groups (all p < 0.05), and ΔSR at 2 weeks during CCRT presented with the highest AUC (0.91), yielding 88.9% sensitivity and 88.9% specificity with a selected cutoff value.<bold>Conclusions: </bold>Strain elastography may be useful as an early predictor of long-term outcomes after CCRT for patients with cervical cancer.<bold>Key Points: </bold>• The D maxas well as ΔD maxat 2 weeks during CCRT can predict the responder outcomes. • The elastography parameters (SR and ΔSR) exhibited predictive values of favorable response after therapy initiation. • ΔSR at 2 weeks during CCRT held the best predictive value for the responder outcomes.
- Subjects
CERVICAL cancer; CERVIX uteri diseases; MAGNETIC resonance imaging; RECTAL cancer; PAP test; PROGNOSIS; ELASTOGRAPHY
- Publication
European Radiology, 2020, Vol 30, Issue 1, p471
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-019-06345-y