We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
DNA vaccines for cancer too.
- Authors
Min Yu; Finn, Olivera J.
- Abstract
The article presents an update on clinical trials of DNA cancer vaccines. DNA vaccines usually consist of the gene encoding the antigen of interest inserted into bacterial plasmid DNA containing promoter/enhancer elements of choice to drive antigen expression. Dendritic cells (DC) are professional antigen-presenting cells that play a crucial role in priming immune responses for effective elimination of tumors and long-term tumor-specific memory. In DNA vaccination, DC are involved in two major pathways of antigen presentation, the direct pathway and the cross-presentation pathway.
- Subjects
DNA vaccines; CANCER; GENES; DNA; TUMORS; DENDRITIC cells; ANTIGENS
- Publication
Cancer Immunology, Immunotherapy, 2006, Vol 55, Issue 2, p119
- ISSN
0340-7004
- Publication type
Article
- DOI
10.1007/s00262-005-0008-7