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- Title
Hepatitis E virus infection in chimpanzees: a retrospective analysis.
- Authors
McCaustland, K. A.; Krawczynski, K.; Ebert, J. W.; Balayan, M. S.; Andjaparidze, A. G.; Spelbring, J. E.; Cook, E. H.; Humphrey, C.; Yarbough, P. O.; Favorov, M. O.; Carson, D.; Bradley, D. W.; Robertson, B. H.
- Abstract
Summary. Different patterns of disease were observed among 11 chimpanzees who were inoculated intravenously with hepatitis E virus (HEV) positive fecal specimens from four different outbreaks (Nepal 1981, Uzbekistan 1981, Pakistan 1985, and Mexico 1986). Five chimpanzees had marginal or no liver enzyme elevations within 70 days of inoculation. Two of the chimpanzees had limited viremia, but did not produce detectable antibody. The four remaining chimpanzees had liver enzyme elevations, viral shedding, viremia, seroconversion to anti-HEV, and detectable HEV antigen in liver biopsy specimens. These results may reflect the range of infection patterns that develop in humans after natural exposure to the HEV.
- Subjects
CHIMPANZEES; HEPATITIS E; HEPATITIS viruses; VIRAL hepatitis; LIVER diseases; ENZYMES
- Publication
Archives of Virology, 2000, Vol 145, Issue 9, p1909
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s007050070065