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- Title
Advanced glycation end-product peptides are associated with impaired renal function, but not with biochemical markers of endothelial dysfunction and inflammation, in non-diabetic individuals.
- Authors
Frank Stam; Casper G. Schalkwijk; Coen van Guldener; Piet M. ter Wee; Coen D. A. Stehouwer
- Abstract
Background. Patients with end-stage renal disease as well as mild renal impairment have an increased risk for the development of cardiovascular disease. It has been suggested that advanced glycation end-products (AGEs) are involved in atherogenesis, possibly through induction of endothelial dysfunction and low-grade inflammation.Methods. In a cross-sectional, single-centre study, we investigated four groups of 20 non-diabetic subjects with a creatinine clearance ranging from normal (>90 ml/min/1.73 m2) to <31 ml/min/1.73 m2. We measured AGE-peptides, markers of endothelial dysfunction (von Willebrand factor, soluble E-selectin, plasminogen activator inhibitor-1, tissue-type plasminogen activator, soluble vascular cell adhesion molecule-1) and markers of inflammatory activity (soluble intercellular adhesion molecule-1, C-reactive protein, secretory phospholipase A2). We constructed composite endothelial dysfunction and inflammatory activity Z-scores using these markers.Results. AGE-peptides were independently related to creatinine clearance (standardized β −0.55, 95% confidence interval (CI) −0.77 to −0.34, P<0.001). AGE-peptides were not independently related to the individual markers of endothelial dysfunction and inflammation, nor to the composite endothelial dysfunction Z-score (standardized β 0.08, 95% CI −0.14 to −0.30, P = 0.48) or the inflammatory activity Z-score (standardized β −0.05, 95% CI −0.25 to −0.16, P = 0.66).Conclusions. Plasma concentrations of AGE-peptides are associated with creatinine clearance but not with biochemical markers of endothelial dysfunction and inflammatory activity in non-diabetic patients over a wide range of renal function. This suggests that the atherogenic effects of AGE-peptides in individuals with renal functional impairment are not mediated by endothelial dysfunction or inflammatory activity as estimated by the markers used.
- Publication
Nephrology Dialysis Transplantation, 2006, Vol 21, Issue 3, p677
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfi309