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- Title
How dietary phosphate, renal failure and calcitriol administration affect the serum calcium–phosphate relationship in the rat.
- Authors
Jara, Aquiles; Chacón, Cecilia; Felsenfeld, Arnold J.
- Abstract
Background. The effect of hyperphosphataemia on serum calcium regulation in renal failure has not been well studied in a setting in which hypercalcaemia is not parathyroid hormone (PTH) mediated. In azotemic rats with a normal serum calcium concentration, an increased dietary phosphate burden affects serum calcium regulation because of its effects on skeletal resistance to PTH, calcitriol production, and possibly intestinal calcium absorption. Our goal was to determine how hyperphosphataemia affected the development of hypercalcaemia during calcitriol‐induced hypercalcaemia and PTH suppression in azotemic rats with established hyperparathyroidism.
- Publication
Nephrology Dialysis Transplantation, 2002, Vol 17, Issue 5, p765
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/17.5.765