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- Title
Effects of anaemia on cardiovascular status.
- Authors
O'Riordan, Edmond; Foley, Robert N.
- Abstract
Cardiomyopathy is a common, heterogeneous and important cause of cardiac morbidity and mortality in uraemic patients. The risks of ischaemic heart disease, cardiac failure, and death increase progressively from lowest risk in patients with concentric left‐ventricular hypertrophy, to medium risk in patients with left‐ventricular dilatation but intact systolic function, to highest risk in patients with systolic dysfunction. Anaemia and hypertension are the reversible risk factors most consistently linked with the development of cardiomyopathy in these patients. Longitudinal data show that anaemia predisposes individuals to initial left ventricular dilatation, with compensatory hypertrophy, which may progress to systolic dysfunction. This process typically begins at glomerular filtration rates between 25 and 50 ml/min, and haemoglobin concentrations that are even slightly below normal are associated with progressive cardiac enlargement.
- Publication
Nephrology Dialysis Transplantation, 2000, Vol 15, p19
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/oxfordjournals.ndt.a027971