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- Title
Efficiency of oxetanocin-G, a novel nucleoside against the woodchuck hepatitis virus.
- Authors
Ikeda, Naoki; Kaneko, Shuichi; Shimoda, Atsushi; Inagaki, Yutaka; Unoura, Masashi; Okada, Mineaki; Yonekawa, Yoshiaki; Takahashi, Katsutoshi; Kobayashi, Kenichi; Ikeda, N; Kaneko, S; Shimoda, A; Inagaki, Y; Unoura, M; Okada, M; Yonekawa, Y; Takahashi, K; Kobayashi, K
- Abstract
Oxetanocin-G (OXT-G), a potent antiviral agent, is a novel nucleoside isolated from the culture filtrate of Bacillus megaterium. We investigated the antiviral effect of oral administration of OXT-G for five days on woodchuck hepatitis virus (WHV), in vivo, using 12 woodchucks. Woodchucks were randomized into each of four treatment groups according to the dose of OXT-G. Two out of six woodchucks treated with 1.0 or 2.0 mg/kg/day of OXT-G died. After treatment with OXT-G, serum levels of WHV-DNA significantly decreased in all woodchucks. However, the antiviral effect was only partial and levels of serum WHV-DNA returned after the cessation of treatment. The amount of viral replicative intermediates was decreased in livers of woodchucks treated with OXT-G. Although further study of the toxicity of this compound would be essential before studies in man can be carried out, OXT-G has potent antiviral activity against WHV and may deserve evaluation as an antiviral agent in the treatment of chronic hepatitis B infections in humans.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1994, Vol 33, Issue 1, p83
- ISSN
0305-7453
- Publication type
journal article