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- Title
Efficacy of amoxycillin/clavulanic acid in experimental Bacteroides fragilis/Escherichia coli mixed infections.
- Authors
Beale, Angela S.; Gisby, J.; Beale, A S; Sutherland, R
- Abstract
The efficacy of amoxycillin/clavulanic acid was compared with those of metronidazole, cefuroxime, metronidazole/ampicillin, metronidazole/gentamicin and metronidazole/cefuroxime, in experimental mixed infections produced in mice by subcutaneous inoculation of amoxycillin-resistant strains of Bacteroides fragilis and Escherichia coli. The combination of metronidazole/ampicillin failed to inhibit the growth of E. coli, and exerted only a transient effect on the numbers of Bact. fragilis in the groin abscesses. In contrast, amoxycillin/clavulanic acid prevented the development of the infection, eliminating both organisms. Metronidazole and cefuroxime, alone and in combination, were less effective than amoxycillin/clavulanic acid in inhibiting the growth of the infecting organisms. These results demonstrate the clinical potential of amoxycillin/clavulanic acid in prophylaxis, or in the therapy of mixed aerobe/anaerobe infections.
- Subjects
ANTIBIOTICS; ANTIBIOTICS assay; CEFUROXIME; METRONIDAZOLE; GENTAMICIN; AMPICILLIN; AMOXICILLIN; ANIMAL experimentation; COMBINATION drug therapy; COMPARATIVE studies; ENZYME inhibitors; ESCHERICHIA coli; ESCHERICHIA coli diseases; GRAM-negative bacterial diseases; RESEARCH methodology; MEDICAL cooperation; MICE; RESEARCH; EVALUATION research; GRAM-negative anaerobic bacteria; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1988, Vol 21, Issue 4, p451
- ISSN
0305-7453
- Publication type
journal article