We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Efficacy and safety research of Lophatherum gracile extract.
- Authors
ZHOU Qiu-na; LI Ting-ting; YANG Meng; ZHOU Chun-ya; KIM Young-heui
- Abstract
Lophatherum gracile extract (LG) was taken as the research object, and its efficacy and safety were evaluated, aiming to enhance its application prospect in the field of cosmetics. Eye irritation and skin irritation were evaluated by HET-CAM test and human patch test. Through the cell model in which the transient receptor potential vanilloid subtype 1 (TRPV1) was highly expressed, the influences on the expression of interleukin 8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) were measured. Skin stimulation models for sensitive skin were established using sodium dodecyl sulfate (SDS), lactic acid and capsaicin as irritants. These models were used to determine the ability of LG to relieve skin sensitivity. HET-CAM test and human patch test show that LG has good safety to eyes and skin. In the cell model with over-expression of TRPV1, LG can reduce the expression of IL-8 and MCP-1 in a dose-dependent manner. In human evaluation, LG can significantly reduce the transepidermal water loss rate (TEWL) and skin erythema index (EI) caused by SDS (p < 0.05), instantly alleviate the skin irritation caused by lactic acid, and significantly reduce the skin discomfort and redness caused by capsaicin, indicating that LG can accelerate the repair of damaged skin and enhance the barrier function of sensitive skin (p < 0.05). Therefore, as an active raw material of plant origin, LG has the characteristics of high efficiency, strong efficacy and safety, which can be widely used in the development of skin care products.
- Publication
Detergent & Cosmetics, 2023, Vol 46, Issue 9, p36
- ISSN
1006-7264
- Publication type
Article
- DOI
10.3969/j.issn.1006-7264.2023.09.006