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- Title
Insulin Resistance and markers of Endothelial dysfunction in Metabolic Syndrome, Delhi; a case-control study.
- Authors
Lal, Sandhya; Tripathi, Smita; Bhattacharjee, Jayashree; Bhatnagar, M. K.
- Abstract
Background: Insulin resistance is strongly associated with components of the metabolic syndrome (MS) including endothelial dysfunction. Our present work aims to study markers of endothelial dysfunction and calculate insulin resistance in patients fulfilling the definition of MS and to compare the results with healthy controls. Methodology: A hospital based observational, case-control study was conducted. It included 46 cases of MS (according to International Diabetes Federation-2006 criteria) attending medicine OPD of a tertiary care hospital of New Delhi and 46 healthy volunteers. The study was ethically cleared by hospitals' ethical committee and written consent was taken from the study population. Routine chemistries, plasma insulin levels, Endothelin-1 (ET-1) and Nitric oxide (NO) were estimated. Insulin resistance was assessed using HOMA-IR. Appropriate statistical tests were applied using SPSS. Results: The results of the study are expressed as Mean± Standard error of Mean. The mean fasting plasma Insulin level was significantly high among cases [11.7 ±1.7 mU/L vs 6.93±0.6mU/L, (p<0.05)]. The mean value of HOMA-IR was significantly high among cases [5.3 ±1.2 vs 1.3 ±0.1, (p<0.001)]. The mean plasma NO level was significantly high among cases [22.5 ±2.9 μmole/L vs 14.1±2.5 μmole/L, (p<0.05)]. The mean plasma Endothelin-1 (ET-1) level was significantly high among cases [(8.6 ± 0.6 pg/mL vs. 5.0 ± 0. 3pg/dL (p<0.001)].Significant positive correlation was seen in Insulin and NO levels (p value <0.05, r=0.348) whereas no significant correlation was seen in between Insulin and ET-1. On regression analysis, association of Insulin and NO was seen (Standardized coefficient beta=0.348, t=2.4, p value<0.05). Conclusion: In present study, patients with metabolic syndrome had significantly higher Insulin, Insulin resistance, higher levels of Endothelin-1and higher Nitric oxide levels. The characteristic finding of endothelial dysfunction of reduced Nitric oxide is absent. It points to other mechanisms leading progression of the disease process. An understanding of the primary mechanisms resulting in these phenotypes may reveal new therapeutic targets in metabolic and cardiovascular disease.
- Subjects
INSULIN resistance; BIOMARKERS; ENDOTHELIUM diseases; METABOLIC syndrome; NITRIC oxide
- Publication
Indian Journal of Basic & Applied Medical Research, 2017, Vol 6, Issue 4, p281
- ISSN
2250-284X
- Publication type
Article