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- Title
Clinically Recognized Varicose Veins and Physical Function in Older Individuals: The ARIC Study.
- Authors
Mok, Yejin; Ishigami, Junichi; Sang, Yingying; Kucharska-Newton, Anna M; Salameh, Maya; Schrack, Jennifer A; Palta, Priya; Coresh, Josef; Windham, B Gwen; Lutsey, Pamela L; Folsom, Aaron R; Matsushita, Kunihiro
- Abstract
<bold>Background: </bold>Although a few studies reported an association between varicose veins and physical function, this potentially bidirectional association has not been systematically evaluated in the general population.<bold>Method: </bold>In 5 580 participants (aged 71-90 years) from the Atherosclerosis Risk in Communities study, varicose veins were identified in outpatient and inpatient administrative data prior to (prevalent cases) and after (incident cases) visit 5 (2011-2013). Physical function was evaluated by the Short Physical Performance Battery (SPPB, score ranging from 0 to 12). We evaluated (i) cross-sectional association between prevalent varicose veins and physical function, (ii) association of prevalent varicose veins with subsequent changes in physical function from visit 5 to visits 6 (2016-2017) and 7 (2018-2019), and (iii) association of physical function at visit 5 with incident varicose veins during a median follow-up of 3.6 years (105 incident varicose veins among 5 350 participants without prevalent cases at baseline).<bold>Results: </bold>At baseline, varicose veins were recognized in 230 (4.1%) participants and cross-sectionally associated with reduced physical function. Longitudinally, prevalent varicose veins were not significantly associated with a decline in SPPB over time. In contrast, a low SPPB ≤6 was associated with a greater incidence of varicose veins compared to SPPB ≥10 (adjusted hazard ratio 2.13 [95% confidence interval = 1.19, 3.81]).<bold>Conclusion: </bold>In community-dwelling older adults, varicose veins and low physical function were associated cross-sectionally. Longitudinally, low physical function was a risk factor for incident varicose veins, but not vice versa. Our findings suggest an etiological contribution of low physical function to incident varicose veins.
- Subjects
CROSS-sectional method; DISEASE incidence; VARICOSE veins; RESEARCH funding; PROPORTIONAL hazards models
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2022, Vol 77, Issue 8, p1637
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glab287