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- Title
Associations of Actigraphic Sleep Parameters With Fatigability in Older Adults.
- Authors
Alfini, Alfonso J; Schrack, Jennifer A; Urbanek, Jacek K; Wanigatunga, Amal A; Wanigatunga, Sarah K; Zipunnikov, Vadim; Ferrucci, Luigi; Simonsick, Eleanor M; Spira, Adam P
- Abstract
<bold>Background: </bold>Poor sleep may increase the likelihood of fatigue, and both are common in later life. However, prior studies of the sleep-fatigue relationship used subjective measures or were conducted in clinical populations; thus, the nature of this association in healthier community-dwelling older adults remains unclear. We studied the association of actigraphic sleep parameters with perceived fatigability-fatigue in response to a standardized task-and with conventional fatigue symptoms of low energy or tiredness.<bold>Methods: </bold>We studied 382 cognitively normal participants in the Baltimore Longitudinal Study of Aging (aged 73.1 ± 10.3 years, 53.1% women) who completed 6.7 ± 0.9 days of wrist actigraphy and a perceived fatigability assessment, including rating of perceived exertion (RPE) after a 5-minute treadmill walk or the Pittsburgh Fatigability Scale (PFS). Participants also reported non-standardized symptoms of fatigue.<bold>Results: </bold>After adjustment for age, sex, race, height, weight, comorbidity index, and depressive symptoms, shorter total sleep time (TST; <6.3 hours vs intermediate TST ≥6.3 to 7.2 hours) was associated with high RPE fatigability (odds ratio [OR] = 2.56, 95% confidence interval [CI] = 1.29, 5.06, p = .007), high PFS physical (OR = 1.88, 95% CI = 1.04, 3.38, p = .035), and high mental fatigability (OR = 2.15, 95% CI = 1.02, 4.50, p = .044), whereas longer TST was also associated with high mental fatigability (OR = 2.19, 95% CI = 1.02, 4.71, p = .043). Additionally, longer wake bout length was associated with high RPE fatigability (OR = 1.53, 95% CI = 1.14, 2.07, p = .005), and greater wake after sleep onset was associated with high mental fatigability (OR = 1.14, 95% CI = 1.01, 1.28, p = .036).<bold>Conclusion: </bold>Among well-functioning older adults, abnormal sleep duration and sleep fragmentation are associated with greater perceived fatigability.
- Subjects
OLDER people; RATE of perceived exertion; SLEEP; FATIGUE (Physiology); SYMPTOMS
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2020, Vol 75, Issue 9, pe95
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glaa137