We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Transgenerational Obesity and Healthy Aging in Drosophila.
- Authors
Camilleri-Carter, Tara-Lyn; Dowling, Damian K; Robker, Rebecca L.; Piper, Matthew D W; L Robker, Rebecca
- Abstract
Substantial evidence suggests that individuals born to overweight and obese parents suffer detrimental health consequences that dramatically decrease healthy aging. The number of obese individuals worldwide now exceeds the number of under- and malnourished individuals. This obesity epidemic is responsible for approximately 4 million deaths worldwide each year, and predisposes sufferers to a range of age-related diseases such as cardiovascular diseases, and metabolic syndrome. Additionally, obesity is associated with an accelerated onset of age-related ailments, such as cancers and inflammation. The importance of dietary interventions to reduce the incidence of obesity is magnified by emerging evidence that parental physiology can predispose future generations to poor health outcomes. Characterizing and understanding these effects, and how they are mediated, is important if we are to continue to drive improvements to population health. In this article, we synthesize evidence for the intergenerational and transgenerational phenotypic effects of parental obesity. We concentrate on how the fruit fly Drosophila melanogaster can be used as a model to study these effects. Fruit flies are highly tractable, and their conserved nutrient signaling and metabolic pathways make them an ideal model for studying nutritional effects on metabolic, reproductive, and aging phenotypes.
- Subjects
DROSOPHILA; FRUIT flies; OBESITY; DROSOPHILA melanogaster; CARDIOVASCULAR diseases; PSYCHOLOGICAL aspects of aging; OBESITY &; psychology; OBESITY complications; ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; FAMILY health; FOOD habits; INSECTS; INTERGENERATIONAL relations; RESEARCH methodology; MEDICAL cooperation; RESEARCH; PHENOTYPES; EVALUATION research
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2019, Vol 74, Issue 10, p1582
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glz154