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- Title
The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm.
- Authors
Ferrari, Filippo Alberto; Magni, Francesca; Bosco, Mariachiara; Biancotto, Giulia; Zorzato, Pier Carlo; Laganà, Antonio Simone; Chiantera, Vito; Raffaelli, Ricciarda; Franchi, Massimo; Uccella, Stefano; Garzon, Simone
- Abstract
There is evidence that diet and nutrition are modifiable risk factors for several cancers. In recent years, attention paid to micronutrients in gynecology has increased, especially regarding Human papillomavirus (HPV) infection. We performed a review of the literature up until December 2022, aiming to clarify the effects of micronutrients, minerals, and vitamins on the history of HPV infection and the development of cervical cancer. We included studies having as their primary objective the evaluation of dietary supplements, in particular calcium; zinc; iron; selenium; carotenoids; and vitamins A, B12, C, D, E, and K. Different oligo-elements and micronutrients demonstrated a potential protective role against cervical cancer by intervening in different stages of the natural history of HPV infection, development of cervical dysplasia, and invasive disease. Healthcare providers should be aware of and incorporate the literature evidence in counseling, although the low quality of evidence provided by available studies recommends further well-designed investigations to give clear indications for clinical practice.
- Subjects
THERAPEUTIC use of vitamin C; THERAPEUTIC use of vitamin E; THERAPEUTIC use of iron; THERAPEUTIC use of zinc; THERAPEUTIC use of vitamin A; VITAMIN therapy; THERAPEUTIC use of vitamin D; THERAPEUTIC use of minerals; THERAPEUTIC use of vitamin B12; ONLINE information services; DISEASE progression; CERVIX uteri diseases; CONFIDENCE intervals; SYSTEMATIC reviews; CERVICAL intraepithelial neoplasia; IRON in the body; DIETARY supplements; RISK assessment; CAROTENOIDS; PAPILLOMAVIRUS diseases; DESCRIPTIVE statistics; MICRONUTRIENTS; DYSPLASIA; CERVIX uteri tumors; MEDLINE; DIETARY calcium; ODDS ratio; SELENIUM; VITAMIN K; DISEASE risk factors; DISEASE complications
- Publication
Healthcare (2227-9032), 2023, Vol 11, Issue 11, p1652
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare11111652