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- Title
弥漫性血管内凝血产妇围术期凝血与纤溶系统指标的检测及临床意义.
- Authors
周黎明; 陈秋莎; 邓燕; 陈启荣; 罗琴
- Abstract
Objective: To explore the clinical significance of perioperative detection of coagulation and fibrinolysis system indicators in parturients with diffuse intravascular coagulation (DIC). Methods:The 57 DIC pregnant women (DIC group) who were treated in our hospital from January 2017 to December 2017 were selected as the research objects. 57 normal pregnant women (healthy pregnant women group) and 57 healthy non-pregnant women (non-pregnant women group) who underwent maternity examination in our hospital during the same period were selected by stratified sampling method as the control group. The changes of prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D) and platelet count (PLT) in each group were compared. According to the treatment results of DIC group, the patients were divided into effective group and ineffective group. The PT, TT, APTT, FIB, D-D and PLT of the two subgroups were compared before treatment. Pearson correlation analysis was used to analyze the correlation between the detection indicators before treatment in DIC group. Results: Compared with healthy pregnant women group and non-pregnant women group, the levels of PT, TT and APTT in DIC group prolonged(P<0.05), the level of D-D increased (P<0. 05), the levels of FIB and PLT decreased(P<0.05). Compared with non-pregnant women group, the levels of PT, TT and APTT in healthy pregnant women group were shorter(P<0.05), the level of D-D decreased (P<0.05), the levels of FIB and PLT increased(P<0.05). The levels of PT, TT and APTT in the effective group before treatment were shorter than those in the ineffective group(P<0.05), the level of D-D was lower than that in the ineffective group(P<0.05). The levels of FIB and PLT were higher than those in the ineffective group (P<0.05). Pearson correlation analysis showed that there was no significant correlation between PT and APTT(P>0.05), but there was some correlation between other indicators of coagulation and fibrinolysis system(P<0.05). Conclusion: Perioperative abnormal changes of coagulation and fibrinolysis system indicators in pregnant women with DIC. Detection of coagulation and fibrinolysis system indicators is of great significance for the diagnosis and treatment of pregnant women with DIC.
- Subjects
DISSEMINATED intravascular coagulation; PARTIAL thromboplastin time; PREGNANT women; THROMBIN time; PLATELET count
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 12, p2076
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.11.015