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- Title
Childhood-Diagnosed ADHD, Symptom Progression, and Reversal Learning in Adulthood.
- Authors
McCarthy, Hazel; Stanley, Jessica; Piech, Richard; Skokauskas, Norbert; Mulligan, Aisling; Donohoe, Gary; Mullins, Diane; Kelly, John; Johnson, Katherine; Fagan, Andrew; Gill, Michael; Meaney, James; Frodl, Thomas
- Abstract
<bold>Objective: </bold>ADHD persists in up to 60% into adulthood, and the reasons for persistence are not fully understood. The objective of this study was to characterize the neurofunctional basis of decision making in those with a childhood diagnosis of ADHD with either persistent or remitted symptoms in adulthood versus healthy control participants.<bold>Method: </bold>Thirty-two adults diagnosed with ADHD as children were split into persistent ( n = 18) or remitted ( n = 14) ADHD groups. Their neural activity and neurofunctional connectivity during a probabilistic reversal learning task were compared with 32 healthy controls.<bold>Results: </bold>Remitters showed significantly higher neural connectivity in final reversal error and probabilistic error conditions, and persisters depict higher neural connectivity in reversal errors than controls at a family-wise error (FWE) corrected whole-brain corrected threshold.<bold>Conclusion: </bold>Remitters may have utilized higher neural connectivity than controls to make successful decisions. Also, remitters may have utilized compensatory strategies to override any potential underlying ADHD deficits.
- Publication
Journal of Attention Disorders, 2018, Vol 22, Issue 6, p561
- ISSN
1087-0547
- Publication type
journal article
- DOI
10.1177/1087054716661233