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- Title
Efficacy and Safety of Omega-3/6 Fatty Acids, Methylphenidate, and a Combined Treatment in Children With ADHD.
- Authors
Barragán, Eduardo; Breuer, Dieter; Döpfner, Manfred
- Abstract
<bold>Objective: </bold>To compare efficacy of Omega-3/6 fatty acids (Equazen eye q™) with methylphenidate (MPH) and combined MPH + Omega-3/6 in children with ADHD.<bold>Method: </bold>Participants ( N = 90) were randomized to Omega-3/6, long-acting MPH, or combination for 12 months. ADHD symptoms were assessed using the ADHD Rating Scale and Clinical Global Impressions-Severity (CGI-S) scale.<bold>Results: </bold>ADHD symptoms decreased in all treatment arms. Although significant differences favoring Omega + MPH over Omega-3/6 alone were found for ADHD Total and Hyperactivity-Impulsivity subscales, results on the Inattention subscale were similar. CGI-S scores decreased slowly and consistently with Omega-3/6, compared with a rapid decrease and subsequent slight increase in the MPH-containing arms. Adverse events were numerically less frequent with Omega-3/6 or MPH + Omega-3/6 than MPH alone.<bold>Conclusion: </bold>The tested combination of Omega-3/6 fatty acids had similar effects to MPH, whereas the MPH + Omega combination appeared to have some tolerability benefits over MPH.
- Subjects
CENTRAL nervous system stimulants; ATTENTION-deficit hyperactivity disorder; BEHAVIOR; COMBINATION drug therapy; COMPARATIVE studies; CONTROLLED release preparations; RESEARCH methodology; MEDICAL cooperation; METHYLPHENIDATE; OMEGA-3 fatty acids; OMEGA-6 fatty acids; RESEARCH; PILOT projects; EVALUATION research; TREATMENT effectiveness; THERAPEUTICS
- Publication
Journal of Attention Disorders, 2017, Vol 21, Issue 5, p433
- ISSN
1087-0547
- Publication type
journal article
- DOI
10.1177/1087054713518239