We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Role of the Promoter Polymorphism IL-6-174G/C in Dermatomyositis and Systemic Lupus Erythematosus.
- Authors
Hristova, Maria; Dourmishev, Lyubomir; Kamenarska, Zornitsa; Nikolova, Svetla; Kaneva, Radka; Vinkov, Anton; Baleva, Marta; Monova, Daniela; Mitev, Vanio
- Abstract
The promoter polymorphism -174G/C within the interleukin-6 gene (IL-6) has been reported to have a functional importance through the modulation of IL-6 gene expression in vitro and in vivo. IL-6 is thought to play an important role in autoimmune diseases and the effect of its receptor inhibitor--tocilizumab--has been recently studied. The aim of this case-control study was to investigate the association between the interleukin-6-174G/C single nucleotide polymorphism and the susceptibility to dermatomyositis (DM) and systemic lupus erythematosus (SLE) in Bulgarian patients. Altogether, 87 patients--52 with SLE and 35 with DM--as well as 80 unrelated healthy controls were included in this study. All of them were analyzed by restriction fragment length polymorphism analysis (RFLP). The GG genotype and the G allele appeared to be associated with SLE, especially in women. None of the genotypes showed an association with DM. However, the G allele appeared to be associated with muscle weakness and it is a risk factor for elevated muscle enzymes. Our results indicate that IL-6-174G/C polymorphism might be associated with the susceptibility to SLE especially in women. Although it is not associated with DM, it seems that IL-6-174G/C polymorphism could modulate some clinical features in the autoimmune myopathies.
- Publication
BioMed Research International, 2013, Vol 2013, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2013/315365