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- Title
Oxidative Stress Treatment for Clinical Trials in Neurodegenerative Diseases.
- Authors
Ienco, Elena Caldarazzo; LoGerfo, Annalisa; Carlesi, Cecilia; Orsucci, Daniele; Ricci, Giulia; Mancuso, Michelangelo; Siciliano, Gabriele
- Abstract
Oxidative stress is a metabolic condition arising from imbalance between the production of potentially reactive oxygen species and the scavenging activities. Mitochondria are the main providers but also the main scavengers of cell oxidative stress. The role of mitochondrial dysfunction and oxidative stress in the pathogenesis of neurodegenerative diseases is well documented. Therefore, therapeutic approaches targeting mitochondrial dysfunction and oxidative damage hold great promise in neurodegenerative diseases. Despite this evidence, human experience with antioxidant neuroprotectants has generally been negative with regards to the clinical progress of disease, with unclear results in biochemical assays. Here we review the antioxidant approaches performed so far in neurodegenerative diseases and the future challenges in modern medicine.
- Subjects
OXIDATIVE stress; NEURODEGENERATION; ANTIOXIDANTS; MITOCHONDRIAL pathology; OXIDATION-reduction reaction
- Publication
Journal of Alzheimer's Disease, 2011, Vol 23, Issue S1, p111
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2011-110164