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- Title
STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody.
- Authors
Lee, Ji-Sun; Kang, Ju-Hee; Boo, Hye-Jin; Hwang, Su-Jung; Hong, Sungyoul; Lee, Su-Chan; Park, Young-Jun; Chung, Tae-Moon; Youn, Hyewon; Mi Lee, Seung; Jae Kim, Byoung; Chung, June-Key; Chung, Yeonseok; William, William N.; Kee Shin, Young; Lee, Hyo-Jong; Oh, Seung-Hyun; Lee, Ho-Young
- Abstract
Drug resistance is a major impediment in medical oncology. Recent studies have emphasized the importance of the tumour microenvironment (TME) to innate resistance, to molecularly targeted therapies. In this study, we investigate the role of TME in resistance to cixutumumab, an anti-IGF-1R monoclonal antibody that has shown limited clinical efficacy. We show that treatment with cixutumumab accelerates tumour infiltration of stromal cells and metastatic tumour growth, and decreases overall survival of mice. Cixutumumab treatment stimulates STAT3-dependent transcriptional upregulation of IGF-2 in cancer cells and recruitment of macrophages and fibroblasts via paracrine IGF-2/IGF-2R activation, resulting in the stroma-derived CXCL8 production, and thus angiogenic and metastatic environment. Silencing IGF-2 or STAT3 expression in cancer cells or IGF-2R or CXCL8 expression in stromal cells significantly inhibits the cancer-stroma communication and vascular endothelial cells' angiogenic activities. These findings suggest that blocking the STAT3/IGF-2/IGF-2R intercellular signalling loop may overcome the adverse consequences of anti-IGF-1R monoclonal antibody-based therapies.
- Subjects
DRUG resistance in cancer cells; TUMOR treatment; MONOCLONAL antibodies; STROMAL cells; MACROPHAGES
- Publication
Scientific Reports, 2015, p8499
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/ncomms9499