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- Title
The common functional FKBP5 variant rs1360780 is associated with altered cognitive function in aged individuals.
- Authors
Fujii, Takashi; Ota, Miho; Hori, Hiroaki; Hattori, Kotaro; Teraishi, Toshiya; Matsuo, Junko; Kinoshita, Yukiko; Ishida, Ikki; Nagashima, Anna; Kunugi, Hiroshi
- Abstract
The common single nucleotide polymorphism (SNP) rs1360780 (C/T) of the FK506 Binding Protein 5 (FKBP5) gene has been reported to be associated with an altered response of the hypothalamic-pituitary-adrenal (HPA) axis and the development of stress-related psychiatric disorders such as posttraumatic stress disorder (PTSD). In the present study, we examined whether this SNP is associated with cognitive function in a non-clinical population. The full versions of the Wechsler Memory Scale-Revised and Wechsler Adult Intelligence Scale-Revised were administered to 742 and 627 Japanese individuals, respectively, followed by genotyping of rs1360780 by the TaqMan 5'-exonuclease allelic discrimination assay. For both cognitive tests, we found significantly poorer attention/concentration (working memory) in aged (>50 years old) individuals carrying the T allele compared with their counterparts. This finding accords with an altered HPA axis and vulnerability to stress-related psychiatric disorders.
- Subjects
COGNITIVE ability; SINGLE nucleotide polymorphisms; CARRIER proteins; HYPOTHALAMIC-pituitary-adrenal axis; PATHOLOGICAL psychology; OLDER people
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep06696