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- Title
Coordinated and Independent Roles for MLH Subunits in DNA Repair.
- Authors
Pannafino, Gianno; Alani, Eric; Lopez, Bernard S.; Matic, Ivan
- Abstract
The MutL family of DNA mismatch repair proteins (MMR) acts to maintain genomic integrity in somatic and meiotic cells. In baker's yeast, the MutL homolog (MLH) MMR proteins form three heterodimeric complexes, MLH1-PMS1, MLH1-MLH2, and MLH1-MLH3. The recent discovery of human PMS2 (homolog of baker's yeast PMS1) and MLH3 acting independently of human MLH1 in the repair of somatic double-strand breaks questions the assumption that MLH1 is an obligate subunit for MLH function. Here we provide a summary of the canonical roles for MLH factors in DNA genomic maintenance and in meiotic crossover. We then present the phenotypes of cells lacking specific MLH subunits, particularly in meiotic recombination, and based on this analysis, propose a model for an independent early role for MLH3 in meiosis to promote the accurate segregation of homologous chromosomes in the meiosis I division.
- Subjects
DNA mismatch repair; MEIOSIS; DNA repair; CHROMOSOME segregation; SACCHAROMYCES cerevisiae; HOMOLOGOUS chromosomes; PHENOTYPES
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 4, p948
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10040948