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- Title
Lipase-Mediated Amidation of Anilines with 1,3-Diketones via C-C Bond Cleavage.
- Authors
Liu Zhang; Fengxi Li; Chunyu Wang; Lu Zheng; Zhi Wang; Rui Zhao; Lei Wang
- Abstract
In this work, an efficient and green lipase-mediated technique has been mined for the amidation of anilines with 1,3-diketones via C-C bond cleavage. Under the optimal conditions, high yields (64.3%-96.2%) could be obtained when Novozym 435 was used as the catalyst. Furthermore, Novozym 435 exhibited a satisfying reusability and more than 80% of yield can be obtained after seven cycles. This work provides a more rapid and mild strategy for amide synthesis with high yield and expands the application of enzyme in organic synthesis.
- Subjects
LIPASES; AMIDATION; CATALYTIC activity
- Publication
Catalysts (2073-4344), 2017, Vol 7, Issue 4, p115
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal7040115