We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with Type 1 diabetes mellitus.
- Authors
Paterson, M. A.; Smart, C. E. M.; Lopez, P. E.; Howley, P.; McElduff, P.; Attia, J.; Morbey, C.; King, B. R.
- Abstract
Aim To determine the glycaemic impact of increasing protein quantities when consumed with consistent amounts of carbohydrate in individuals with Type 1 diabetes on intensive insulin therapy. Methods Participants with Type 1 diabetes [aged 10-40 years, HbA1c ≤ 64 mmol/mol (8%), BMI ≤ 91st percentile] received a 30-g carbohydrate (negligible fat) test drink daily over 5 days in randomized order. Protein (whey isolate 0 g/kg carbohydrate, 0 g/kg lipid) was added in amounts of 0 (control), 12.5, 25, 50 and 75 g. A standardized dose of insulin was given for the carbohydrate. Postprandial glycaemia was assessed by 5 h of continuous glucose monitoring. Results Data were collected from 27 participants (15 male). A dose-response relationship was found with increasing amount of protein. A significant negative relationship between protein dose and mean excursion was seen at the 30- and 60-min time points ( P = 0.007 and P = 0.002, respectively). No significant relationship was seen at the 90- and 120-min time points. Thereafter, the dose-response relationship inverted, such that there was a significant positive relationship for each of the 150-300-min time points ( P < 0.004). Mean glycaemic excursions were significantly greater for all protein-added test drinks from 150 to 300 min ( P < 0.005) with the 75-g protein load, resulting in a mean excursion that was 5 mmol/l higher when compared with the control test drink ( P < 0.001). Conclusions Increasing protein quantity in a low-fat meal containing consistent amounts of carbohydrate decreases glucose excursions in the early (0-60-min) postprandial period and then increases in the later postprandial period in a dose-dependent manner.
- Subjects
BLOOD sugar analysis; DOSE-response relationship in biochemistry; INGESTION; INSULIN; TYPE 1 diabetes; DIETARY proteins
- Publication
Diabetic Medicine, 2017, Vol 34, Issue 6, p851
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/dme.13347