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- Title
Nateglinide provides tighter glycaemic control than glyburide in patients with Type 2 diabetes with prevalent postprandial hyperglycaemia.
- Authors
Bellomo Damato, A.; Stefanelli, G.; Laviola, L.; Giorgino, R.; Giorgino, F.
- Abstract
Aims: Postprandial hyperglycaemia in patients with Type 2 diabetes mellitus has been linked to the development of cardiovascular disease. This study compared the effects of mealtime (thrice-daily) nateglinide with once-daily glyburide on postprandial glucose levels in patients with Type 2 diabetes and postprandial hyperglycaemia. Methods: Patients with Type 2 diabetes aged ‡ 21 years with 2-h postprandial glucose levels ‡ 11.1 mmol ⁄ l, HbA1c of 6.5–8.5% (48–69 mmol⁄ mol) and BMIof 22–30 kg ⁄m2 were randomized to 6 weeks’ double-blind treatment with nateglinide 120 mg three times daily prior tomeals, or glyburide 5 mg once daily before breakfast. The primary endpoint was the baselineadjusted change in plasma glucose frompreprandial (fasting plasma glucose) to 2-h postprandial glucose levels (2-h postprandial glucose excursion) at 6 weeks. Results: Patients were randomized to nateglinide (n = 122) or glyburide (n = 110).The treatment groups were similar in terms of age, gender, BMI, fasting plasma glucose, 2-h postprandial glucose and HbA1c. At endpoint, nateglinide recipients had significantly greater reductions than those receiving glyburide in both the 2-h ()2.4 vs.)1.6 mmol ⁄ l;P = 0.02)and1-h()1.7 vs. )0.9 mmol⁄ l; P = 0.016) postprandial glucose excursions.Adverse events,most commonly symptomatic hypoglycaemia,were reported in26%of recipients of glyburide and22%of recipients of nateglinide. Episodes of suspected mild hypoglycaemiawere reported in 24% of recipients of glyburide and 10% of recipients of nateglinide. Conclusions: Nateglinide leads to greater reductions in postprandial glucose excursions and is associated with a lower risk of hypoglycaemia than glyburide in this selected population of patients with Type 2 diabetes.
- Subjects
ITALY; OUTPATIENT medical care; ANALYSIS of covariance; ANALYSIS of variance; BLOOD sugar; COMPARATIVE studies; CONFIDENCE intervals; GLYCOSYLATED hemoglobin; HEALTH facilities; HOSPITALS; HYPERGLYCEMIA; HYPOGLYCEMIC agents; HYPOGLYCEMIC sulfonylureas; MEDICAL cooperation; TYPE 2 diabetes; RESEARCH; STATISTICAL sampling; STATISTICAL hypothesis testing; RANDOMIZED controlled trials; BLIND experiment; THERAPEUTICS
- Publication
Diabetic Medicine, 2011, Vol 28, Issue 5, p560
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2010.03219.x