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- Title
Effect of lixisenatide on natriuretic peptides in people with type 2 diabetes and recent acute coronary syndrome: The ELIXA trial.
- Authors
Gerstein, Hertzel C.; Wolsk, Emil; Claggett, Brian; Diaz, Rafael; Dickstein, Kenneth; Hess, Sibylle; Køber, Lars; Maggioni, Aldo P.; McMurray, John J. V.; Probstfield, Jeffrey L.; Riddle, Matthew C.; Tardif, Jean‐Claude; Pfeffer, Marc A.
- Abstract
Keywords: GLP-1 receptor agonists; lixisentatide; natriuretic peptides; randomized controlled trial EN GLP-1 receptor agonists lixisentatide natriuretic peptides randomized controlled trial 1125 1129 5 03/08/23 20230401 NES 230401 BACKGROUND Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) lower glucose, weight and blood pressure, and reduce cardiovascular and kidney outcomes in people with type 2 diabetes (T2D).[1], [2], [3] Although mechanisms for their effects remain unclear, small recent studies have reported that they may reduce natriuretic peptides.[4] B-type natriuretic peptide (BNP) and its inactive precursor N-terminal-pro BNP (NT-proBNP) were measured at baseline and follow-up in the Evaluation of Lixisenatide in Acute Coronary Syndrome (ELIXA) trial. GLP-1 receptor agonists, lixisentatide, natriuretic peptides, randomized controlled trial 2 Abbreviation: ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BNP, B-type natriuretic peptide; COPD, chronic obstructive pulmonary disease; GFR, glomerular filtration rate; NT-proBNP, N terminal, pro-hormone B-type natriuretic peptide. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials.
- Subjects
NATRIURETIC peptides; ACUTE coronary syndrome; TYPE 2 diabetes; BRAIN natriuretic factor; BLOOD pressure; HEART beat; GLUCAGON-like peptide-1 receptor
- Publication
Diabetes, Obesity & Metabolism, 2023, Vol 25, Issue 4, p1125
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.14954