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- Title
A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization.
- Authors
Hughes, Jenevieve H.; Mason, Mark C.; Gray, Richard J.; McLaughlin, Sarah A.; Degnim, Amy C.; Fulmer, Jack T.; Pockaj, Barbara A.; Karstaedt, Patricia J.; Roarke, Michael C.
- Abstract
This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered “negative” if ≥2 mm from in-situ and invasive disease. Pain and convenience scores were recorded on a 10-point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p < 0.001). A second operation was required in 8% of RSL patients to achieve negative margins, versus 25% of WL patients (p < 0.001). Pain scores were not statistically different. However, the RSL group had higher convenience scores (p = 0.015). RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re-excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL.
- Subjects
CLINICAL trials; BIOPSY; BREAST cancer; SURGICAL excision; REOPERATION; PATIENT satisfaction; MEDICAL imaging systems
- Publication
Breast Journal, 2008, Vol 14, Issue 2, p153
- ISSN
1075-122X
- Publication type
Article
- DOI
10.1111/j.1524-4741.2007.00546.x