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- Title
Local leukocyte proliferation as a target for cyclophosphamide in the treatment of Henoch- Schönlein purpura nephritis grade VI.
- Authors
Kaneko, Masahiro; Ikezumi, Yohei; Yamada, Takeshi; Hasegawa, Hiroya; Kaneko, Utako; Saitoh, Akihiko
- Abstract
Henoch-Schönlein purpura nephritis ( HSPN) is one of the most common types of chronic glomerulonephritis in children; however, there have been few reports on the pathogenesis and management of grade VI HSPN. We present the case of a 6-year-old boy with grade VI HSPN accompanied by severe nephrotic syndrome and hypocomplementaemia. Immunohistological studies revealed profound glomerular accumulation of CD45- and CD68-positive inflammatory cells. Moreover, some cells expressed the proliferating marker proliferating cell nuclear antigen. His proteinuria and general oedema persisted despite repeated high-dose steroid therapy; however, these clinical symptoms immediately improved after beginning treatment with cyclophosphamide ( CyP). Grade VI HSPN was successfully treated with steroids and immunosuppressants. Among immunosuppressive drugs, CyP was considered the most effective.
- Subjects
LEUCOCYTES; CELL proliferation; CYCLOPHOSPHAMIDE; SCHOENLEIN-Henoch purpura; GLOMERULONEPHRITIS; JUVENILE diseases; THERAPEUTICS
- Publication
Nephrology, 2016, Vol 21, Issue 1, p68
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/nep.12558