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- Title
Lifestyle interventions for the treatment of non-alcoholic fatty liver disease.
- Authors
Bradford, V.; Dillon, J. F.; Miller, M. H.
- Abstract
The burden of non-alcoholic fatty liver disease (NAFLD) worldwide is a significantclinical and public health issue, affecting approximately one third of the Western population.This review assesses the effect and impact lifestyle interventions have on the treatment of thiscommon condition. We review studies comparing the effect of calorie restriction and exerciseprograms, as well as comparison of lifestyle intervention with pharmaceutical intervention. Bothcalorie restriction and exercise programs are shown to be beneficial in improving features ofmetabolic syndrome and surrogate markers of NAFLD. The paucity of studies using histologicalimprovement hinders the ability to conclude a benefit on improvement of histological NAFLD,although this is shown in a small number of studies. There is a need to extend the interventionperiod to show a sustained improvement with intervention as most studies have a follow upperiod of 12 months of less.
- Subjects
THERAPEUTICS; FATTY liver; LIFESTYLES &; health; LOW-calorie diet; EXERCISE therapy; METABOLIC disorder treatment
- Publication
Hepatic Medicine: Evidence & Research, 2013, Vol 6, p1
- ISSN
1179-1535
- Publication type
Article
- DOI
10.2147/HMER.S34472