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- Title
Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers.
- Authors
Siu Tsan Yuen; Tsun Leung Chan; Ho, Judy WC; Chan, Annie SY; Lap Ping Chung; Lam, Polly WY; Chun Wah Tse; Wyllie, Andrew H.; Suet Yi Leung
- Abstract
Focuses on a study which examined the colorectal and other HNPCC-related cancers with microsatellite instability which provided information on the mechanisms of inactivation the two major proteins involved, hMLH1 and hMSH2. Basis for the stratification of the tumors; Mechanisms of hMSH2 protein loss; Problems in the analysis of hMLH1 promoter hypermethylation.
- Subjects
MICROSATELLITE repeats; COLON cancer
- Publication
Oncogene, 2002, Vol 21, Issue 49, p7585
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1205968