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- Title
Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin.
- Authors
Guinea Viniegra, Juan; Hernandez Losa, Javier; Javier Sanchez-Arevalo, Victor; Parada Cobo, Carlos; Manuel Fernandez Soria, Victor; Ramon y Cajal, Santiago; Sanchez-Prieto, Ricardo
- Abstract
Presents a study that investigated which signal transduction pathways could be affected by the E1a gene in Human Normal Fibroblast in order to investigate the molecular mechanisms implicated in the induction of chemo sensitivity by adenovirus E1a gene expression. Absence of effect in Stress Activated Protein Kinase pathways; Effect on Akt activation mediated by insulin; Result of the transient transfection experiments performed in Cos-7 cells.
- Subjects
CELLULAR signal transduction; GENES; FIBROBLASTS
- Publication
Oncogene, 2002, Vol 21, Issue 46, p7130
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1205934