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- Title
Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.
- Authors
Xu Shi-wen; Eastwood, Mark; Stratton, Richard J.; Denton, Christopher P.; Leask, Andrew; Abraham, David J.
- Abstract
Objective. The transcription factor peroxisome proliferator-activated receptor (PPAR)-γ plays an important role in controlling cell differentiation. The aim of the present study was to examine whether PPAR-γ expression was reduced in skin scleroderma fibroblasts and whether PPAR-γ agonists could suppress the persistent fibrotic phenotype of skin scleroderma fibroblasts.
- Subjects
TRANSCRIPTION factors; PEROXISOMES; CELL differentiation; SCLERODERMA (Disease); PHENOTYPES
- Publication
Rheumatology, 2010, Vol 49, Issue 2, p259
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kep371