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- Title
Outcomes of Third-Line Docetaxel-Based Chemotherapy in Advanced Gastric Cancer Who Failed Previous Oxaliplatin-Based and Irinotecan-Based Chemotherapies.
- Authors
Min Jeong Lee; In Gyu Hwang; Joung-Soon Jang; Jin Hwa Choi; Byeong-Bae Park; MyungHee Chang; Seung Tae Kim; Se Hoon Park; Myoung Hee Kang; Jung Hun Kang
- Abstract
Purpose Little is known about outcomes in the use of third-line chemotherapy in cases of advanced gastric cancer (AGC). The primary aim of this retrospective study was to evaluate outcomes of docetaxel-based chemotherapy in patients with AGC that progressed after both oxaliplatin-based and irinotecan-based regimens. Materials and Methods Eligible patients were those with AGC who had previous chemotherapy including fluoropy-rimidine and oxaliplatin as well as fluoropyrimidine and irinotecan and who received subsequent docetaxel-based chemotherapy. Thirty-five patients were retrospectively recruited from 5 medical centers in Korea. Patients received either weekly or 3 weekly with docetaxel +/- cisplatin. Results Thirty-one out of 35 patients were evaluated for treatment response. A total of 94 cycles of chemotherapy (median, 2; range, 1 to 7) were administered. The overall response rate was 14.3%, and the disease control rate was 45.7%. The median progression-free survival (PFS) was 1.9 months (95% confidence interval [Cl], 1.1 to 2.7 months). The median overall survival (OS) was 3.6 months (95% Cl, 2.8 to 4.4 months). PFS and OS were significantly prolonged in patients of the Eastern Cooperative Oncology Group, with performance status of 0 or 1 in multivariate analysis (PFS: hazard ratio[HR], 0.411; 95% Cl, 0.195 to 0.868; p=0.020 and OS: HR, 0.390; 95% Cl, 0.184 to 0.826; p=0.014, respectively). Four of the 35 patients enrolled in the study died due to infection associated with neutropenia. Conclusion Our findings suggest that salvage docetaxel-based chemotherapy is a feasible treatment option for AGC patients with good performance status (PS), whereas chemotherapy for patients with poor PS (PS ≤ 2) should be undertaken with caution for those who previously failed oxaliplatin- and irinotecan-based regimens.
- Subjects
STOMACH cancer treatment; CANCER chemotherapy; OXALIPLATIN; IRINOTECAN; ANTINEOPLASTIC agents; DOCETAXEL; THERAPEUTICS
- Publication
Cancer Research & Treatment, 2012, Vol 44, Issue 4, p235
- ISSN
1598-2998
- Publication type
Article
- DOI
10.4143/crt.2012.44.4.235