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- Title
Efficacy and Safety of Ezetimibe for Japanese Patients with Dyslipidaemia.
- Authors
Sawayama, Yasunori; Maeda, Shinji; Ohnishi, Hachiro; Shin Hayashi; Hayashi, Jun
- Abstract
Background: There are insufficient data available on the efficacy and safety of lipid-lowering therapy for patients with dyslipidaemia complicated by multiple metabolic abnormalities. Objective: This study aimed to examine the efficacy and safety of ezetimibe 10mg/day administered to Japanese patients with dyslipidaemia. Methods: This was a prospective study carried out at Kyushu University Hospital, Fukuoka, Japan. In one group, ezetimibe 10mg/day alone was given to 33 patients for 12 weeks. In the other two groups, ezetimibe was given with an HMG-CoA reductase inhibitor (statin) to 13 patients for 12 weeks: pravastatin 10 mg/day (n = 7) or rosuvastatin 2.5mg/day (n = 6). The main outcome measure was the effect of ezetimibe on low-density lipoprotein cholesterol (LDL-C) and other lipid levels from baseline to 12 weeks. Results: After 12 weeks of treatment, all groups showed marked reductions in mean ±SD LDL-C level (from 155.4 ± 22.0mg/dL at baseline to 118.0 ± 28.1 mg/dL, i.e. -37.4mg/dL; p < 0.001). The mean reduction in LDL-C level with ezetimibe monotherapy was significantly greater in patients with impaired LDL-C metabolism, glucose metabolism or hypertension than in those without such abnormalities (-21.0% vs -8.4%, p< 0.01; -22.7% vs -9.5%, p < 0.05; and -22.5% vs -5.9%, p < 0.05; respectively). The reduction in LDLC levels with ezetimibe monotherapy was also correlated with the number of metabolic abnormalities (r = 0.426, p = 0.013). Conclusions: Both ezetimibe monotherapy and combination therapy with ezetimibe and a statin were able to safely and effectively control LDL-C levels in Japanese patients with dyslipidaemia, including those with metabolic abnormalities.
- Subjects
JAPAN; EZETIMIBE; ANTILIPEMIC agents; DRUG efficacy; HEALTH outcome assessment; BLOOD circulation disorders
- Publication
Clinical Drug Investigation, 2010, Vol 30, Issue 3, p157
- ISSN
1173-2563
- Publication type
Article
- DOI
10.2165/11531530-000000000-00000