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- Title
Shielding Effect of Ryanodine Receptor Modulator in Rat Model of Autism.
- Authors
Kumar, Hariom; Kulkarni, G. T.; Diwan, Vishal; Sharma, Bhupesh
- Abstract
Introduction: A neurodevelopmental disorder, autism is typically identified with three primary behavioral consequences, such as social impairment, communication problems, and limited or stereotypical behavior. Because of its co-morbidity and lack of therapeutic options, autism is a global economic burden. A short chain of fatty acid, propionic acid is formed biologically by the gut microbiome. Propionic acid levels that are too high can cause leaky intestines, which can lead to autism-like symptoms. Methods: To induce autism, male Albino Wistar rats were given propionic acid (250 mg/kg/po on the 21st, 22nd, and 23rd postnatal days). Rats also received a ryanodine receptor antagonist (Ruthenium red: 3 mg/kg/po; postnatal 21st to 50th day) to see what influence it had on propionic acid-induced autism. Anxiety, social behavior, and repeated behaviors were all assessed, as well as oxidative stress, inflammatory indicators, neuro signaling proteins, and blood-brain barrier permeability. Results: Ruthenium red was found to counter the propionic acid-induced increases in anxiety, repetitive behavior prefrontal cortex levels of IL-6, TNF-a, TBARS, Evans blue leakage, and water content along with decreases in social behavior, IL-10, and GSH followed by hippocampus CREB and BDNF levels. Conclusion: Ryanodine receptor antagonists presented a neuroprotective effect in propionic acid-induced conditions like autism by modulatory effects on social and repetitive behavior, oxidative stress, neuroinflammation, and neuroprotein changes. Ryanodine receptors can be further explored in depth to manage autism as a condition.
- Subjects
RYANODINE receptors; COMMUNICATIVE disorders; SHORT-chain fatty acids; AUTISM; ASPERGER'S syndrome; ANIMAL disease models; PROPIONIC acid; SOCIAL anxiety
- Publication
Basic & Clinical Neuroscience, 2023, Vol 14, Issue 2, p247
- ISSN
2008-126X
- Publication type
Article
- DOI
10.32598/bcn.2021.2966.1