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- Title
CD8<sup>+</sup> tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types.
- Authors
Barros, Leandro; Piontkivska, Daryna; Figueiredo-Campos, Patrícia; Fanczal, Júlia; Ribeiro, Sofia Pereira; Baptista, Marta; Ariotti, Silvia; Santos, Nuno; Amorim, Maria João; Pereira, Cristina Silva; Veldhoen, Marc; Ferreira, Cristina
- Abstract
Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory T cells (TRM). CD8+ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (TREG) are important for CD8+ T-cell development, however, if CD8+ TRM cells develop under other infection types and require immune type-specific TREG cells is unknown. We used three distinct lung infection models, to show that type-2 helminth infection does not establish CD8+ TRM cells. Intracellular (type-1) and extracellular (type-3) infections do and rely on the recruitment of response type-matching TREG population contributing transforming growth factor-β. Nevertheless, type-1 TREG cells remain the most important population for TRM cell development. Once established, TRM cells maintain their immune type profile. These results may have implications in the development of vaccines inducing CD8+ TRM cells. Type-1 regulatory T cells promoted the generation of CD8+ tissue-resident memory T (TRM) cells during intracellular infections in the gut. Here, the authors show that the establishment TRM cells more broadly depends on the presence of regulatory T cells matching the type of infection.
- Subjects
T cells; IMMUNOLOGIC memory; REGULATORY T cells; HELMINTHIASIS; CELL populations; VACCINE development
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-41364-w