We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships.
- Authors
Fetcho, Robert N.; Hall, Baila S.; Estrin, David J.; Walsh, Alexander P.; Schuette, Peter J.; Kaminsky, Jesse; Singh, Ashna; Roshgodal, Jacob; Bavley, Charlotte C.; Nadkarni, Viraj; Antigua, Susan; Huynh, Thu N.; Grosenick, Logan; Carthy, Camille; Komer, Lauren; Adhikari, Avishek; Lee, Francis S.; Rajadhyaksha, Anjali M.; Liston, Conor
- Abstract
Social hierarchies exert a powerful influence on behavior, but the neurobiological mechanisms that detect and regulate hierarchical interactions are not well understood, especially at the level of neural circuits. Here, we use fiber photometry and chemogenetic tools to record and manipulate the activity of nucleus accumbens-projecting cells in the ventromedial prefrontal cortex (vmPFC-NAcSh) during tube test social competitions. We show that vmPFC-NAcSh projections signal learned hierarchical relationships, and are selectively recruited by subordinate mice when they initiate effortful social dominance behavior during encounters with a dominant competitor from an established hierarchy. After repeated bouts of social defeat stress, this circuit is preferentially activated during social interactions initiated by stress resilient individuals, and plays a necessary role in supporting social approach behavior in subordinated mice. These results define a necessary role for vmPFC-NAcSh cells in the adaptive regulation of social interaction behavior based on prior hierarchical interactions. Here, the authors identify a frontostriatal circuit that is involved in regulating social interactions based on learned hierarchical relationships.
- Subjects
SOCIAL interaction; SOCIAL defeat; SOCIAL dominance; APPROACH behavior; CELL nuclei; PREFRONTAL cortex
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-37460-6