We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response.
- Authors
Dekkers, Koen F.; Slieker, Roderick C.; Ioan-Facsinay, Andreea; van Iterson, Maarten; BIOS consortium; Ikram, M. Arfan; van Greevenbroek, Marleen M. J.; Veldink, Jan H.; Franke, Lude; Boomsma, Dorret I.; Slagboom, P. Eline; Jukema, J. Wouter; Heijmans, Bastiaan T.
- Abstract
Immune cell function can be altered by lipids in circulation, a process potentially relevant to lipid-associated inflammatory diseases including atherosclerosis and rheumatoid arthritis. To gain further insight in the molecular changes involved, we here perform a transcriptome-wide association analysis of blood triglycerides, HDL cholesterol, and LDL cholesterol in 3229 individuals, followed by a systematic bidirectional Mendelian randomization analysis to assess the direction of effects and control for pleiotropy. Triglycerides are found to induce transcriptional changes in 55 genes and HDL cholesterol in 5 genes. The function and cell-specific expression pattern of these genes implies that triglycerides downregulate both cellular lipid metabolism and, unexpectedly, allergic response. Indeed, a Mendelian randomization approach based on GWAS summary statistics indicates that several of these genes, including interleukin-4 (IL4) and IgE receptors (FCER1A, MS4A2), affect the incidence of allergic diseases. Our findings highlight the interplay between triglycerides and immune cells in allergic disease. Circulating lipids can influence immune cell function, which could have implications for inflammatory diseases such as rheumatoid arthritis. Here, the authors use Mendelian randomization to identify genes whose expression is influenced by triglyceride levels in blood, implicating genes involved in lipid metabolism and allergic response.
- Subjects
LIPID metabolism; BLOOD lipids; HDL cholesterol; LDL cholesterol; ANALYSIS of triglycerides; LIPIDS; INTERLEUKIN-4; TH2 cells; COLLATERAL circulation
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-35663-x