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- Title
Selective Enzyme Inhibitors as Antileukemic Agents.
- Authors
Coleman, Mary Sue
- Abstract
A clinical problem in antileukemic chemotherapy is that normal, rapidly proliferating cells of the marrow are destroyed along with malignant cells. Because children with hereditary lack of the enzyme adenosine deaminase suffer destruction of their lymphocytes, inhibitors of this enzyme have been investigated for selective destruction of lymphocytes in neoplastic lymphoproliferative disease (leukemia). Such targeted chemotherapy is an example of the usefulness of a basic understanding of the enzymatic and antigenic composition of leukemic cells. (Accepted for publication 22 March 1983)
- Subjects
ENZYME inhibitors; LEUKEMIA; CANCER chemotherapy; CELL proliferation; CHEMICAL inhibitors; CANCER cells; LEUCOCYTES; THERAPEUTICS; CELL cycle; BONE marrow
- Publication
BioScience, 1983, Vol 33, Issue 11, p707
- ISSN
0006-3568
- Publication type
Article
- DOI
10.2307/1309351