We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Role of Renal Nerves in the Treatment of Renovascular Hypertensive Rats with L-Arginine.
- Authors
Gouvea, Sonia Alves; Tiradentes, Renata V.; Santuzzi, Cintia H.; Mengal, Vinícius; de A. Futuro Neto, Henrique; Silva, Nyam F.; Abreu, Gláucia R.
- Abstract
The purpose was to determine the role of renal nerves in mediating the effects of antihypertensive treatment with L-arginine in a renovascular hypertension model. The 2K1C (two-kidney one-clip model) hypertensive rats were submitted to bilateral surgicalpharmacological renal denervation. The animals were subdivided into six experimental groups: normotensive control rats (SHAM), 2K1C rats, 2K1C rats treated with L-arginine (2K1C + L-arg), denervated normotensive (DN) rats, denervated 2K1C (2K1C + DN) rats, and denervated 2K1C + L-arg (2K1C + DN + L-arg) rats. Arterial blood pressure, water intake, urine volume, and sodium excretion were measured. The 2K1C rats exhibited an increase in the mean arterial pressure (MAP) (from 106 ± 3to 183 ± 5.8 mmHg, P < 0.01), whereas L-arg treatment induced a reduction in the MAP (143 ± 3.4 mmHg) without lowering it to the control level. Renal nerve denervation reduced the MAP to normotensive levels in 2K1C rats with or without chronic L-arg treatment. L-arg and denervation induced increases in water intake and urine volume, and L-arg caused a significant natriuretic effect. Our results suggest that renal sympathetic activity participates in the genesis and the maintenance of the hypertension and also demonstrate that treatment with L-arg alone is incapable of normalizing the MAP and that the effect of such treatment is not additive with the effect of kidney denervation.
- Publication
International Journal of Hypertension, 2014, p1
- ISSN
2090-0384
- Publication type
Journal Article
- DOI
2014/735627