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- Title
Estrogen receptor 1 gene rs2295193 polymorphism and anorexia nervosa: New data and meta-analysis.
- Authors
Zhang, Chen; Chen, Jue; Jia, Xiuzhen; Yu, Shunying; Jiang, Wenhui; Zhang, Ran; Yuan, Aihua; Qian, Yiping; Fan, Juan; Zhang, Mingdao; Fang, Yiru; Xiao, Zeping
- Abstract
Introduction Estrogen plays essential roles in the regulation of food intake, adiposity, and body weight control. The estrogen alpha receptor, encoded by estrogen receptor 1 gene ( ESR1), has been implicated with anorexia nervosa ( AN). A previous study indicated that the rs2295193 polymorphism in ESR1 may confer a genetic susceptibility to AN. Methods In a case-control study, we assessed 195 AN probands and 93 healthy controls; 99 trios were studied in a family-based association analysis through genotyping the rs2295193 polymorphism in ESR1. Additionally, we carried out a meta-analysis of the combined sample groups. Results There were no significant differences in the genotype or allele frequencies of the rs2295193 polymorphism between the AN and control groups ( Ps > 0.05). In the transmission disequilibrium test ( TDT) analyses, there was no evidence for biased transmission of the G allele of rs2295193 polymorphism ( P = 0.32). In female-only samples, no significant association was observed between the rs2295193 polymorphism and AN in either case-control or transmission disequilibrium test analyses ( Ps > 0.05). The meta-analysis revealed that no excess of transmission of the G allele in AN families (pooled odds ratio = 1.10, P = 0.79). Discussion Meta-analytically combined evidence from the present genotyping and the literature showed that rs2295193 polymorphism in ESR1 is not a major genetic susceptibility factor in AN.
- Subjects
ESTROGEN receptors; GENETIC polymorphisms; ANOREXIA nervosa; INGESTION; OBESITY; META-analysis
- Publication
Asia-Pacific Psychiatry, 2013, Vol 5, Issue 4, p331
- ISSN
1758-5864
- Publication type
Article
- DOI
10.1111/appy.12100