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- Title
Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium.
- Authors
Collatuzzo, Giulia; Negri, Eva; Pelucchi, Claudio; Bonzi, Rossella; Turati, Federica; Rabkin, Charles S.; Liao, Linda M.; Sinha, Rashmi; Palli, Domenico; Ferraroni, Monica; López-Carrillo, Lizbeth; Lunet, Nuno; Morais, Samantha; Albanes, Demetrius; Weinstein, Stephanie J.; Parisi, Dominick; Zaridze, David; Maximovitch, Dmitry; Dierssen-Sotos, Trinidad; Jiménez-Moleón, José Juan
- Abstract
Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.
- Subjects
YOGURT; STOMACH tumors; META-analysis; CONFIDENCE intervals; FOOD consumption; DIET; RISK assessment; QUESTIONNAIRES; DESCRIPTIVE statistics; RESEARCH funding; ODDS ratio; LOGISTIC regression analysis; DISEASE risk factors
- Publication
Nutrients, 2023, Vol 15, Issue 8, p1877
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15081877