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- Title
Wogonin, a Compound in Scutellaria baicalensis , Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells.
- Authors
Yamada, Yasunari; Saito, Hodaka; Araki, Masaya; Tsuchimoto, Yuhei; Muroi, Shin-ichi; Suzuki, Kyohei; Toume, Kazufumi; Kim, Jun-Dal; Matsuzaka, Takashi; Sone, Hirohito; Shimano, Hitoshi; Nakagawa, Yoshimi
- Abstract
Fibroblast growth factor 21 (FGF21), which is mainly synthesized and secreted by the liver, plays a crucial role in systemic glucose and lipid metabolism, ameliorating metabolic diseases. In this study, we screened the WAKANYAKU library derived from medicinal herbs to identify compounds that can activate Fgf21 expression in mouse hepatocyte AML12 cells. We identified Scutellaria baicalensis root extract and one of its components, wogonin, as an activator of Fgf21 expression. Wogonin also enhanced the expression of activating transcription factor 4 (ATF4) by a mechanism other than ER stress. Knockdown of ATF4 by siRNA suppressed wogonin-induced Fgf21 expression, highlighting its essential role in wogonin's mode of action. Thus, our results indicate that wogonin would be a strong candidate for a therapeutic to improve metabolic diseases by enhancing hepatic FGF21 production.
- Subjects
PHYTOTHERAPY; THERAPEUTIC use of plant extracts; FIBROBLAST growth factors; BIOLOGICAL models; LIVER; ANIMAL experimentation; RNA; CELLULAR signal transduction; METABOLIC disorders; TREATMENT effectiveness; CELLS; LIVER cells; TRANSCRIPTION factors; MICE
- Publication
Nutrients, 2022, Vol 14, Issue 19, p3920
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14193920